Glycosaminoglycans in the urinary bladder mucosa, tumor tissue and mucosal tissue around tumor.
نویسندگان
چکیده
INTRODUCTION/AIM Glycosaminoglycans (GAG) are one of the main constituents of the connective tissue and cellular membrane. Their presence has been evidenced in mucosa and muscular tissue of the urinary bladder of both healthy individuals and those affected by carcinoma. This suggest their potential role in the onset of bladder carcinoma and follow-up of those patients. The aim of the study was to determine GAG levels in tumor tissue and the surrounding bladder mucosa in patients with bladder tumor, as well as in the bladder mucosa in patients with bladder carcinoma, and to compare the results according to the grade and stage of tumor and relapse. METHODS Tissue samples were taken in 61 patients (48 males and 13 females), mean age 61.5 years, range 40-92 years, obtained by transurethral resection (TUR) of bladder tumor, and 8 healthy persons. Determination of a total GAG content in the tissue samples was done by the Whiteman's method and then compared regarding the tumor grade and stage. RESULTS Tumor grade and stage directly correlated with the levels of GAG. The GAG levels were significantly higher in tumor samples as compared to healthy mucosa. CONCLUSION Higher GAG levels were recorded in all the patients with bladder tumors comparing to samples obtained from healthy individuals. GAG levels do not predict tumor relapse.
منابع مشابه
A Rare Urinary Bladder Fibrosarcoma with a Cystolith in a Dog
Case description: This report describes the simultaneous occurrence of fibrosarcoma and a urolith in the urinary bladder of a 12-year-old female terrier dog that was confirmed by pathology after excisional surgery. Clinical findings: The dog had some clinical signs such as frequent urination, hematuria and dysuria with an...
متن کاملRelationship between grade and MDM2 oncoprotein overexpression in transitional cell carcinoma of the urinary bladder
Objective: Transitional cell carcinoma (TCC) of the urinary bladder is the second common cancer of the genitourinary tract. Several parameters such as clinical and pathological parameters, molecular factors, and etc play a role in determination of prognosis and type of treatment. In this research study, ...
متن کاملA Carcinoid Tumor in the Urinary Bladder With Uncommon Clinicopathological Presentation
Background: Carcinoid tumors usually originate from the enterochromaffin cells located in gastrointestinal tract and bronchopulmonary system. They may rarely arise in the urinary bladder, where this can be eventually miscued as any other commoner bladder neoplasms. The current study was conducted to connote an uncommon clinicopathological presentation by a carcinoid tu...
متن کاملMicroscopic Study of Histological Changes the Use of Ileal Mucosa as a Bladder (Radical Cystectomy - Case Report)
Cancer can significantly have ruining effects on very high of human beings, social, and economic condition. Bladder cancer has been reported as one of the most common cancers and the incidence rates of this cancer is increasing across the world. Cystectomy is a surgery to remove the urinary bladder. In the present study a part of the ileum is used instead of bladder. This study deals with mucos...
متن کاملبررسی بروز مارکر سیکلواکسیژناز-2 به روش ایمونوهیستوشیمی در تومورهای ترانزیشنال مثانه
Background: Transitional Cell Carcinoma (TCC) is the most common type of urinary bladder cancer. Cyclooxygenase-2 (COX-2), a key enzyme in prostaglandins biosynthesis, has been introduced as a new candidate for targeted therapy in this cancer. In this study, we investigated the expression of COX-2 in urinary bladder TCCs and its relationship with clinicopathological parameters such as tumor gra...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Vojnosanitetski pregled
دوره 69 2 شماره
صفحات -
تاریخ انتشار 2012